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EnglishCatalog No : | IPB0274 |
Reactivity: | Human; Mouse; |
Applications: | WB; ELISA |
Dilution: | WB: 1:500-1:2000 ELISA: 1:40000 |
Gene Name: | ACE2 |
Protein Name: | Angiotensin-converting enzyme 2 |
Human Gene Id: | 59272 |
Swiss-Prot: | Q9BYF1 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | [Processed angiotensin-converting enzyme 2]: Secreted Cell membrane; Single-pass type I membrane protein Cytoplasm Cell projection, cilium Apical cell membrane Detected in both cell membrane and cytoplasm in neurons [Isoform 2]: Apical cell membrane |
MW: | 92463 |
Background: | The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7 The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63 |
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