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EnglishCatalog No : | IPB0263 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; IHC-p; IF/ICC; ELISA |
Dilution: | WB: 1:500-1:2000 IHC-p: 1:100-1:200 ELISA: 1:20000 IF: 1:50-1:200 |
Gene Name: | CANX |
Protein Name: | Calnexin |
Human Gene Id: | 821 |
Swiss-Prot: | P27824 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Endoplasmic reticulum membrane; Single-pass type I membrane protein Endoplasmic reticulum Melanosome Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065) The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232) |
MW: | 67568 |
Background: | This gene encodes a member of the calnexin family of molecular chaperones The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation Alternatively spliced transcript variants encoding the same protein have been described |
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