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EnglishCatalog No : | IPB0258 |
Reactivity: | Human; Mouse; Rat |
Applications: | IF/ICC; WB; ELISA |
Dilution: | IF: 1:50-200 WB: 1:500-1:2000 ELISA: 1:10000 |
Gene Name: | TIMP1 |
Protein Name: | Metalloproteinase inhibitor 1 |
Human Gene Id: | 7076 |
Swiss-Prot: | P01033 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Secreted |
MW: | 23171 |
Background: | This gene belongs to the TIMP gene family The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function Transcription of this gene is highly inducible in response to many cytokines and hormones In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction |
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