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| Catalog No ： | IPB0225 |
| Reactivity： | Human; Mouse; Rat |
| Applications： | IHC-p; IF/ICC; WB; ELISA |
| Dilution： | WB: 1:500-2000 IHC: 1:50-1:200 IF: 1:50-1:200 ELISA: 1:5000 |
| Gene Name： | INSR |
| Protein Name： | Insulin receptor |
| Human Gene Id： | 3643 |
| Swiss-Prot： | P06213 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Cell membrane; Single-pass type I membrane protein Late endosome Lysosome Binding of insulin to INSR induces internalization and lysosomal degradation of the receptor, a means for down-regulating this signaling pathway after stimulation In the presence of SORL1, internalized INSR molecules are redirected back to the cell surface, thereby preventing their lysosomal catabolism and strengthening insulin signal reception |
| MW： | 156307 |
| Background： | This gene encodes a member of the receptor tyrosine kinase family of proteins The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome Alternative splicing results in multiple transcript variants |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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