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EnglishCatalog No : | IPB0223 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; IHC-p |
Dilution: | WB: 1:500-2000 IHC-p: 1:100-1:200 |
Gene Name: | NFKBIA IKBA MAD3 NFKBI |
Protein Name: | NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3) |
Human Gene Id: | 4792 |
Swiss-Prot: | P25963 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cytoplasm Nucleus Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export |
MW: | - |
Background: | This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains The encoded protein interacts with REL dimers to inhibit NF-kappa-B:REL complexes which are involved in inflammatory responses The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease |
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