中文
EnglishCatalog No : | IPB0222 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; ELISA |
Dilution: | WB: 1:500-1:2000 ELISA: 1:40000 |
Gene Name: | IGF1R |
Protein Name: | Insulin-like growth factor 1 receptor |
Human Gene Id: | 3480 |
Swiss-Prot: | P08069 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cell membrane; Single-pass type I membrane protein |
MW: | 154793 |
Background: | This receptor binds insulin-like growth factor with a high affinity It has tyrosine kinase activity The insulin-like growth factor I receptor plays a critical role in transformation events Cleavage of the precursor generates alpha and beta subunits It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene |
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