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| Catalog No ： | IPB0203 |
| Reactivity： | Human; Mouse; Rat |
| Applications： | WB; ELISA |
| Dilution： | WB: 1:500-1:2000 ELISA: 1:20000 |
| Gene Name： | BTK |
| Protein Name： | Tyrosine-protein kinase BTK |
| Human Gene Id： | 695 |
| Swiss-Prot： | Q06187 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Cytoplasm Cell membrane; Peripheral membrane protein Nucleus In steady state, BTK is predominantly cytosolic Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain Plasma membrane localization is a critical step in the activation of BTK A fraction of BTK also shuttles between the nucleus and the cytoplasm, and nuclear export is mediated by the nuclear export receptor CRM1 |
| MW： | 76150 |
| Background： | The protein encoded by this gene plays a crucial role in B-cell development Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement Alternative splicing results in multiple transcript variants encoding different isoforms |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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