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EnglishCatalog No : | IPB0192 |
Reactivity: | Human; Mouse; Rat |
Applications: | IF/ICC; WB; IHC-p; ELISA |
Dilution: | IF: 1:50-200 WB: 1:500-1:2000 IHC: 1:50-1:200 ELISA: 1:40000 |
Gene Name: | PTK2 |
Protein Name: | Focal adhesion kinase 1 |
Human Gene Id: | 5747 |
Swiss-Prot: | Q05397 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cell junction, focal adhesion Cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm, cell cortex Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus Cytoplasm, cytoskeleton, cilium basal body Constituent of focal adhesions Detected at microtubules |
MW: | 119233 |
Background: | This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only four of them have been determined |
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