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| Catalog No ： | IPB0179 |
| Reactivity： | Human; Mouse; Rat |
| Applications： | WB; CoIP; IHC-p; IF/ICC; ELISA |
| Dilution： | IP: 1:50 WB: 1:500-1:2000 IHC: 1:50-1:200 IF: 1:50-1:200 ELISA: 1:5000 |
| Gene Name： | SMAD2 |
| Protein Name： | Mothers against decapentaplegic homolog 2 |
| Human Gene Id： | 4087 |
| Swiss-Prot： | Q15796 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Cytoplasm Nucleus Cytoplasmic and nuclear in the absence of TGF-beta On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:9865696, PubMed:21145499) On dephosphorylation by phosphatase PPM1A, released from the SMAD2:SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081) Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity) |
| MW： | 52306 |
| Background： | The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C elegans gene Sma SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4 The association with SMAD4 is important for the translocation |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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