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| Catalog No ： | IPB0161 |
| Reactivity： | Human; Mouse; Rat |
| Applications： | WB; IHC-p; IF/ICC; ELISA |
| Dilution： | WB: 1:500-1:2000 IHC: 1:50-1:200 IF: 1:50-1:200 ELISA: 1:40000 |
| Gene Name： | PTEN |
| Protein Name： | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN |
| Human Gene Id： | 5728 |
| Swiss-Prot： | P60484 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Cytoplasm Nucleus Nucleus, PML body Monoubiquitinated form is nuclear Nonubiquitinated form is cytoplasmic Colocalized with PML and USP7 in PML nuclear bodies (PubMed:18716620) XIAP:BIRC4 promotes its nuclear localization (PubMed:19473982) [Isoform alpha]: Secreted May be secreted via a classical signal peptide and reenter into cells with the help of a poly-Arg motif |
| MW： | 47166 |
| Background： | This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT:PKB signaling pathway The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane This longer isoform may help regulate ener |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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