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| Catalog No ： | IPB0152 |
| Reactivity： | Human; Mouse; Rat |
| Applications： | IF/ICC; WB; IHC-p; ELISA |
| Dilution： | IF: 1:50-200 WB: 1:500-1:2000 IHC-p: 1:100-1:200 ELISA: 1:20000 |
| Gene Name： | HMGB1 |
| Protein Name： | High mobility group protein B1 |
| Human Gene Id： | 3146 |
| Swiss-Prot： | P09429 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Nucleus Chromosome Cytoplasm Secreted Cell membrane; Peripheral membrane protein; Extracellular side Endosome Endoplasmic reticulum-Golgi intermediate compartment In basal state predominantly nuclear Shuttles between the cytoplasm and the nucleus (PubMed:12231511, PubMed:17114460) Translocates from the nucleus to the cytoplasm upon autophagy stimulation (PubMed:20819940) Release from macrophages in the extracellular milieu requires the activation of NLRC4 or NLRP3 inflammasomes (By similarity) Passively released to the extracellular milieu from necrotic cells by diffusion, involving the fully reduced HGMB1 which subsequently gets oxidized (PubMed:19811284) Also released from apoptotic cells (PubMed:16855214, PubMed:18631454) Active secretion from a variety of immune and non-immune cells such as macrophages, monocytes, neutrophils, dendritic cells and natural killer cells in response to various stimuli such as LPS and cytokines involves a nonconventional secretory process via secretory lysosomes (PubMed:12231511, PubMed:14532127, PubMed:15944249) Secreted by plasma cells in response to LPS (By similarity) Found on the surface of activated platelets (PubMed:11154118) An increased chromatin association is observed when associated with the adenovirus protein pVII (PubMed:27362237) |
| MW： | 24894 |
| Background： | This gene encodes a protein that belongs to the High Mobility Group-box superfamily The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration Multiple pseudogenes of this gene have been identified Alternative splicing results in multiple transcript variants that encode the same protein |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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