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EnglishCatalog No : | IPB0147 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; IHC-p; IF/ICC; ELISA |
Dilution: | WB: 1:500-1:2000 IHC: 1:50-1:200 IF: 1:50-1:200 ELISA: 1:20000 |
Gene Name: | CDK2 |
Protein Name: | Cyclin-dependent kinase 2 |
Human Gene Id: | 1017 |
Swiss-Prot: | P24941 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus, Cajal body Cytoplasm Endosome Localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase Nuclear-cytoplasmic trafficking is mediated during the inhibition by 1,25-(OH)(2)D(3) |
MW: | 33930 |
Background: | This gene encodes a member of a family of serine:threonine protein kinases that participate in cell cycle regulation The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle Activity of this protein is especially critical during the G1 to S phase transition This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B) Alternative splicing results in multiple transcript variants |
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