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EnglishCatalog No : | IPB0114 |
Reactivity: | Human; Chicken(testedbyourcustomer) |
Applications: | WB; IHC-p; IF/ICC; ELISA |
Dilution: | WB: 1:500-1:2000 IHC: 1:50-1:200 IF: 1:50-1:200 ELISA: 1:20000 |
Gene Name: | DNMT3B |
Protein Name: | DNA (cytosine-5)-methyltransferase 3B |
Human Gene Id: | 1789 |
Swiss-Prot: | Q9UBC3 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Nucleus |
MW: | 95751 |
Background: | CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation Studies in mice have demonstrated that DNA methylation is required for mammalian development This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation The protein localizes primarily to the nucleus and its expression is developmentally regulated Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome Eight alternatively spliced transcript variants have been described The full length sequences of variants 4 and 5 have not been determined |
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