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| Catalog No ： | IPB0109 |
| Reactivity： | Human; Mouse; Rat |
| Applications： | IF/ICC; WB; IHC-p; ELISA |
| Dilution： | IF: 1:50-200 WB: 1:500-1:2000 IHC: 1:50-1:200 ELISA: 1:40000 |
| Gene Name： | NOTCH2 |
| Protein Name： | Neurogenic locus notch homolog protein 2 |
| Human Gene Id： | 4853 |
| Swiss-Prot： | Q04721 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | [Notch 2 extracellular truncation]: Cell membrane; Single-pass type I membrane protein [Notch 2 intracellular domain]: Nucleus Cytoplasm Following proteolytical processing NICD is translocated to the nucleus Retained at the cytoplasm by TCIM (PubMed:25985737) |
| MW： | 265404 |
| Background： | This gene encodes a member of the Notch family Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types Notch family members play a role in a variety of developmental processes by controlling cell fate decisions The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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