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EnglishCatalog No : | IPB0098 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; IHC-p; IF/ICC; ELISA |
Dilution: | WB: 1:500-1:2000 IHC-p: 1:100-1:200 ELISA: 1:20000 IF: 1:50-1:200 |
Gene Name: | SLC2A4 |
Protein Name: | Solute carrier family 2 facilitated glucose transporter member 4 |
Human Gene Id: | 6517 |
Swiss-Prot: | P14672 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cell membrane; Multi-pass membrane protein Endomembrane system; Multi-pass membrane protein Cytoplasm, perinuclear region Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized (PubMed:8300557) The dileucine internalization motif is critical for intracellular sequestration (PubMed:8300557) Insulin stimulation induces translocation to the cell membrane (By similarity) |
MW: | 54787 |
Background: | This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM) |
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