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EnglishCatalog No : | IPB0093 |
Reactivity: | Human; Mouse; Rat |
Applications: | IF/ICC; WB; IHC-p; ELISA |
Dilution: | IF: 1:50-200 WB: 1:500-1:2000 IHC: 1:50-1:200 ICC: 1:200-1:1000 ELISA: 1:20000 |
Gene Name: | MyD88 |
Protein Name: | Myeloid differentiation primary response protein MyD88 |
Human Gene Id: | 4615 |
Swiss-Prot: | Q99836 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cytoplasm Nucleus |
MW: | 33233 |
Background: | This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways These pathways regulate that activation of numerous proinflammatory genes The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections Alternate splicing results in multiple transcript variants |
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