中文
EnglishCatalog No : | IPB0067 |
Reactivity: | Human; Mouse; Rat; Monkey |
Applications: | WB; IHC-p; ELISA |
Dilution: | WB: 1:500-1:2000 IHC: 1:50-1:200 ELISA: 1:40000 |
Gene Name: | AAPK1:AAPK2 |
Protein Name: | 5'-AMP-activated protein kinase catalytic subunit alpha-1/2 |
Human Gene Id: | 5562:5563 |
Swiss-Prot: | Q13131:P54646 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cytoplasm Nucleus In response to stress, recruited by p53:TP53 to specific promoters |
MW: | 62808/62320 |
Background: | The protein encoded by this gene belongs to the ser:thr protein kinase family It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK) AMPK is a cellular energy sensor conserved in all eukaryotic cells The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP:ATP ratio AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways Alternatively spliced transcript variants encoding distinct isoforms have been observed |
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