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| Catalog No ： | IPB0065 |
| Reactivity： | Human; Mouse; Rat |
| Applications： | WB; IF/ICC; IHC-p |
| Dilution： | WB: 1:500-2000 IHC-p: 1:100-1:200 IF: 1:50-1:200 |
| Gene Name： | NOTCH1 |
| Protein Name： | Neurogenic locus notch homolog protein 1 |
| Human Gene Id： | 4851 |
| Swiss-Prot： | P46531 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Cell membrane; Single-pass type I membrane protein [Notch 1 intracellular domain]: Nucleus Following proteolytical processing NICD is translocated to the nucleus Nuclear location may require MEGF10 |
| MW： | 272500 |
| Background： | This gene encodes a member of the NOTCH family of proteins Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor This receptor plays a role in the development of numerous cell and tissue types Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymph |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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