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NFκB-p65 Polyclonal Antibody

¥1900.00元/format:100ul

目录号:IPB0060

库存:现货
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Catalog No :IPB0060
Reactivity:Human; Mouse; Rat
Applications:WB; IHC-p; ELISA
Dilution:WB: 1:500-1:2000 IHC: 1:50-1:200 ELISA: 1:5000
Gene Name:RELA
Protein Name:Transcription factor p65
Human Gene Id:5970
Swiss-Prot:Q04206
Formulation:Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide
Source:Rabbit
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Concentration:1 mg/ml
Storage&Stability:-20°C/1 year
Subcellular Location:Nucleus Cytoplasm Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B) (PubMed:1493333) Colocalized with DDX1 in the nucleus upon TNF-alpha induction (PubMed:19058135) Colocalizes with GFI1 in the nucleus after LPS stimulation (PubMed:20547752) Translocation to the nucleus is impaired in Lmonocytogenes infection (PubMed:20855622)
MW:60219
Background:NF-kappa-B is a ubiquitous transcription factor involved in several biological processes It is held in the cytoplasm in an inactive state by specific inhibitors Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA Four transcript variants encoding different isoforms have been found for this gene

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