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EnglishCatalog No : | IPB0060 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; IHC-p; ELISA |
Dilution: | WB: 1:500-1:2000 IHC: 1:50-1:200 ELISA: 1:5000 |
Gene Name: | RELA |
Protein Name: | Transcription factor p65 |
Human Gene Id: | 5970 |
Swiss-Prot: | Q04206 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Nucleus Cytoplasm Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B) (PubMed:1493333) Colocalized with DDX1 in the nucleus upon TNF-alpha induction (PubMed:19058135) Colocalizes with GFI1 in the nucleus after LPS stimulation (PubMed:20547752) Translocation to the nucleus is impaired in Lmonocytogenes infection (PubMed:20855622) |
MW: | 60219 |
Background: | NF-kappa-B is a ubiquitous transcription factor involved in several biological processes It is held in the cytoplasm in an inactive state by specific inhibitors Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA Four transcript variants encoding different isoforms have been found for this gene |
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