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EnglishCatalog No : | IPB0059 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; IHC-p; IF/ICC; ELISA |
Dilution: | WB: 1:500-1:2000 IHC: 1:50-1:200 IF: 1:50-1:200 ELISA: 1:5000 |
Gene Name: | CASP9 |
Protein Name: | Caspase9 |
Human Gene Id: | 842 |
Swiss-Prot: | P55211 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | nucleus,mitochondrion,cytosol,apoptosome, |
MW: | 46281 |
Background: | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade This protein is thought to play a central role in apoptosis and to be a tumor suppressor Alternative splicing results in multiple transcript variants |
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