中文
EnglishCatalog No : | IPB0058 |
Reactivity: | Human; Mouse; Rat |
Applications: | IHC-p; WB |
Dilution: | IHC-p: 1:100-1:200 WB: 1:500-2000 |
Gene Name: | PARP1 ADPRT PPOL |
Protein Name: | PARP-1 |
Human Gene Id: | 142 |
Swiss-Prot: | P09874 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Nucleus Nucleus, nucleolus Chromosome Localizes to sites of DNA damage |
MW: | - |
Background: | This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes |
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