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EnglishCatalog No : | IPB0052 |
Reactivity: | Human; Mouse; Rat |
Applications: | IF/ICC; WB; IHC-p; IP; ELISA |
Dilution: | IF: 1:50-200 WB: 1:500-1:2000 IHC: 1:50-1:200 IP: 1:50 ELISA: 1:20000 |
Gene Name: | GSK3B |
Protein Name: | Glycogen synthase kinase-3 beta |
Human Gene Id: | 2932 |
Swiss-Prot: | P49841 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cytoplasm Nucleus Cell membrane The phosphorylated form shows localization to cytoplasm and cell membrane (PubMed:20937854) The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854) |
MW: | 46744 |
Background: | The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily It is involved in energy metabolism, neuronal cell development, and body pattern formation Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease Alternatively spliced transcript variants encoding different isoforms have been found for this gene |
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