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EnglishCatalog No : | IPB0051 |
Reactivity: | Human; Mouse; Rat |
Applications: | IHC-p; ELISA |
Dilution: | IHC-p: 1:100-1:200 ELISA: 1:10000-20000 |
Gene Name: | TGFB3 |
Protein Name: | Transforming growth factor beta-3 (TGF-beta-3) |
Human Gene Id: | 7043 |
Swiss-Prot: | P10600 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix [Transforming growth factor beta-3]: Secreted |
MW: | - |
Background: | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer The mature peptide may also form heterodimers with other TGF-beta family members This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic |
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