中文
EnglishCatalog No : | IPB0041 |
Reactivity: | Human; Mouse; |
Applications: | WB; IHC-p; ELISA |
Dilution: | WB: 1:500-1:2000 IHC: 1:50-1:200 ELISA: 1:5000 |
Gene Name: | TGFBR2 |
Protein Name: | TGF-beta receptor type-2 |
Human Gene Id: | 7048 |
Swiss-Prot: | P37173 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cell membrane; Single-pass type I membrane protein Membrane raft [Isoform 3]: Secreted |
MW: | 64568 |
Background: | This gene encodes a member of the Ser:Thr protein kinase family and the TGFB receptor subfamily The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta This receptor:ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors Alternatively spliced transcript variants encoding different isoforms have been characterized |
SPECIES
APPLICATION
TITLE