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EnglishCatalog No : | IPB0034 |
Reactivity: | Human; Monkey |
Applications: | WB; ELISA |
Dilution: | WB: 1:500-1:2000 ELISA: 1:40000 |
Gene Name: | CASP3 |
Protein Name: | Caspase3 |
Human Gene Id: | 836 |
Swiss-Prot: | P42574 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cytoplasm |
MW: | 31608 |
Background: | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10 It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease Alternative splicing of this gene results in two transcript variants that encode the same protein |
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