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| Catalog No ： | IPB0030 |
| Reactivity： | Human; Mouse; Rat |
| Applications： | WB; IHC-p; IF/ICC; ELISA |
| Dilution： | WB: 1:500-1:2000 IHC-p: 1:100-1:200 ELISA: 1:20000 IF: 1:50-1:200 |
| Gene Name： | CDH1 |
| Protein Name： | Cadherin-1 |
| Human Gene Id： | 999:1000:1001:1002 |
| Swiss-Prot： | P12830:P19022:P22223:P55283 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Cell junction, adherens junction Cell membrane; Single-pass type I membrane protein Endosome Golgi apparatus, trans-Golgi network Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane |
| MW： | 97456/99809/91418/100281 |
| Background： | This gene encodes a classical cadherin of the cadherin superfamily Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and:or metastasis The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization This gene is present in a gene cluster with other members of the cadherin family on chromosome 16 |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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