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| Catalog No ： | IPB0029 |
| Reactivity： | Human; Mouse; Rat |
| Applications： | WB; IHC-p; IF/ICC; ELISA |
| Dilution： | WB: 1:500-1:2000 IHC: 1:50-1:200 IF: 1:50-1:200 ELISA: 1:40000 |
| Gene Name： | PYCARD |
| Protein Name： | Apoptosis-associated speck-like protein containing a CARD |
| Human Gene Id： | 29108 |
| Swiss-Prot： | Q9ULZ3 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Cytoplasm Inflammasome Endoplasmic reticulum Mitochondrion Nucleus Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs These appear as hollow, perinuclear spherical, ball-like structures (PubMed:11103777, PubMed:12191486, PubMed:15030775) Upon NLRP3 inflammasome activation redistributes to the perinuclear space localizing to endoplasmic reticulum and mitochondria (PubMed:12191486, PubMed:15030775) Localized primarily to the nucleus in resting monocytes:macrophages and rapidly redistributed to the cytoplasm upon pathogen infection (PubMed:19234215) Localized to large cytoplasmic aggregate appearing as a speck containing AIM2, PYCARD, CASP8 and bacterial DNA after infection with Francisella tularensis (By similarity) Golgi apparatus membrane (Microbial infection) Upon HRSV infection, the protein is mainly located in lipid rafts in the Golgi membrane |
| MW： | 21627 |
| Background： | This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD) The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery Two transcript variants encoding different isoforms have been found for this gene |
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APPLICATION
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Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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