中文
EnglishCatalog No : | IPB0028 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; IHC-p; IF/ICC; ELISA |
Dilution: | WB: 1:500-1:2000 IHC-p: 1:100-1:200 ELISA: 1:20000 IF: 1:50-1:200 |
Gene Name: | TNF TNFA TNFSF2 |
Protein Name: | Tumor necrosis factor |
Human Gene Id: | 7124 |
Swiss-Prot: | P01375 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cell membrane; Single-pass type II membrane protein [Tumor necrosis factor, membrane form]: Membrane; Single-pass type II membrane protein [Tumor necrosis factor, soluble form]: Secreted [C-domain 1]: Secreted [C-domain 2]: Secreted |
MW: | 16KD |
Background: | This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily This cytokine is mainly secreted by macrophages It can bind to, and thus functions through its receptors TNFRSF1A:TNFR1 and TNFRSF1B:TNFBR This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer Knockout studies in mice also suggested the neuroprotective function of this cytokine |
SPECIES
APPLICATION
TITLE