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| Catalog No ： | IPB0023 |
| Reactivity： | Human; Mouse; Rat |
| Applications： | IHC-p; IF/ICC; WB; ELISA |
| Dilution： | WB: 1:500-1:2000 IHC-p: 1:100-1:200 ELISA: 1:20000 IF: 1:50-1:200 |
| Gene Name： | BAX |
| Protein Name： | Apoptosis regulator BAX |
| Human Gene Id： | 581 |
| Swiss-Prot： | Q07812 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | [Isoform Alpha]: Mitochondrion outer membrane; Single-pass membrane protein Cytoplasm Colocalizes with 14-3-3 proteins in the cytoplasm Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane Upon Sendai virus infection, recruited to the mitochondrion through interaction with IRF3 (PubMed:25609812) [Isoform Beta]: Cytoplasm [Isoform Gamma]: Cytoplasm [Isoform Delta]: Cytoplasm |
| MW： | 21184 |
| Background： | The protein encoded by BAX (BCL2 associated X, apoptosis regulator) belongs to the BCL2 protein family BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities This protein forms a heterodimer with BCL2, and functions as an apoptotic activator This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for BAX |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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