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| Catalog No ： | IPB0002 |
| Reactivity： | Human; Mouse; Rat |
| Applications： | WB;IHC;IF;ELISA |
| Dilution： | WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000. IF 1:100-300 |
| Gene Name： | IL1B |
| Protein Name： | Interleukin-1 beta |
| Human Gene Id： | 3553 |
| Swiss-Prot： | P01584 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Cytoplasm, cytosol Secreted Lysosome Secreted, extracellular exosome The precursor is cytosolic (PubMed:15192144) In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted (PubMed:24201029, PubMed:33377178, PubMed:33883744) Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744) In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744) The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059) |
| MW： | 17kD |
| Background： | The protein encoded by this gene is a member of the interleukin 1 cytokine family This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1:ICE) This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis The induction of cyclooxygenase-2 (PTGS2:COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2 |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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