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| Catalog No. ： | IMB0204 |
| Reactivity： | Human;Mouse;Rat;Monkey |
| Applications： | WB; IHC-p; IF/ICC; FCM; ELISA |
| Gene Name： | AIF:M1 |
| Protein Name： | Apoptosis-inducing factor 1 mitochondrial |
| Human Gene Id： | 9131 |
| Swiss-Prot： | O95831 |
| Formulation： | Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol. |
| Source： | Monoclonal, Mouse |
| Dilution： | WB: 1:500-1:2000 IHC: 1:200-1:1000 IF: 1:200-1:1000 FCM: 1:200-1:400 ELISA: 1:10000 |
| PurIF:ication： | Affinity purIF:ication |
| Concentration： | nan |
| Storage&Stability： | -20°C/1 year |
| Background： | This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identIF:ied on chromosome. |
| Subcellular Location.： | Mitochondrion intermembrane space. Mitochondrion inner membrane. Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIF:mit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIF:sol). AIF:sol is released to the cytoplasm in response to specIF:ic death signals, and translocated to the nucleus, where it induces nuclear apoptosis (PubMed:15775970). Colocalizes with EIF:3G in the nucleus and perinuclear region (PubMed:17094969). [Isoform 3]: Mitochondrion intermembrane space. Mitochondrion inner membrane. Has a stronger membrane anchorage than isoform 1. [Isoform 4]: Mitochondrion. Cytoplasm, cytosol. In pro-apoptotic conditions, is released from mitochondria to cytosol in a calpain/cathepsin-dependent manner. [Isoform 5]: Cytoplasm . |
| BiowMW： | nan |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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