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EnglishCatalog No. : | IMB0200 |
Reactivity: | Human |
Applications: | WB; IHC-p; IF/ICC |
Gene Name: | AFP |
Protein Name: | Alpha-fetoprotein |
Human Gene Id: | 174 |
Swiss-Prot: | P02771 |
Formulation: | PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol. |
Source: | Monoclonal, Mouse |
Dilution: | WB: 1:2000 IF: 1:200 IHC: 1:50-300 |
PurIF:ication: | The antibody was affinity-purIF:ied from mouse ascites by affinity-chromatography using specIF:ic immunogen. |
Concentration: | nan |
Storage&Stability: | -20°C/1 year |
Background: | This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal lIF:e. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bIF:ida and anencephaly. |
Subcellular Location.: | Secreted. |
BiowMW: | nan |
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