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EnglishCatalog No. : | IMB0177 |
Reactivity: | Human |
Applications: | WB; IHC-p; ELISA |
Gene Name: | EIF:4EBP1 |
Protein Name: | Eukaryotic translation initiation factor 4E-binding protein 1 |
Human Gene Id: | 1978 |
Swiss-Prot: | Q13541 |
Formulation: | PurIF:ied antibody in PBS containing 0.03% sodium azide. |
Source: | Monoclonal, Mouse |
Dilution: | WB: 1:500-1:2000 IHC: 1:200-1:1000 ELISA: 1:10000 |
PurIF:ication: | Affinity purIF:ication |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Background: | This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF:4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF:4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF:4E and activation of mRNA translation. [provided by RefSeq, Jul 2008], |
Subcellular Location.: | nucleoplasm, cytoplasm, cytosol, protein complex. |
BiowMW: | nan |
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