中文
EnglishCatalog No. : | IMB0173 |
Reactivity: | Human;Mouse |
Applications: | WB; IHC-p; IF/ICC; ELISA |
Gene Name: | FOXP3 |
Protein Name: | Forkhead box protein P3 |
Human Gene Id: | 50943 |
Swiss-Prot: | Q9BZS1 |
Formulation: | PurIF:ied antibody in PBS containing 0.03% sodium azide. |
Source: | Monoclonal, Mouse |
Dilution: | WB: 1:500-1:2000 IHC: 1:200-1:1000 IF: 1:200-1:1000 ELISA: 1:10000 |
PurIF:ication: | Affinity purIF:ication |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Background: | The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding dIF:ferent isoforms have been identIF:ied. |
Subcellular Location.: | Nucleus. Cytoplasm. Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells (By similarity). |
BiowMW: | nan |
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