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EnglishCatalog No. : | IMB0166 |
Reactivity: | Human;Mouse;Rat |
Applications: | IHC-p; |
Gene Name: | COL2A1 |
Protein Name: | Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin] |
Human Gene Id: | 1280 |
Swiss-Prot: | P02458 |
Formulation: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Source: | Monoclonal, Mouse |
Dilution: | IHC-p: 1:50-300 |
PurIF:ication: | The antibody was affinity-purIF:ied from mouse ascites by affinity-chromatography using specIF:ic immunogen. |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Background: | This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identIF:ied for this gene. [provided by RefSeq, Jul 2008], |
Subcellular Location.: | Secreted, extracellular space, extracellular matrix. |
BiowMW: | nan |
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