中文
EnglishCatalog No. : | IMB0159 |
Reactivity: | Species independent |
Applications: | WB; IHC-p |
Gene Name: | nan |
Protein Name: | nan |
Human Gene Id: | nan |
Swiss-Prot: | nan |
Formulation: | PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol. |
Source: | Monoclonal, Mouse |
Dilution: | WB: 1:1000-2000 IHC: 1:200-500 |
PurIF:ication: | The antibody was affinity-purIF:ied from mouse ascites by affinity-chromatography using epitope-specIF:ic immunogen. |
Concentration: | nan |
Storage&Stability: | -20°C/1 year |
Background: | Methylation of lysine residues is a common regulatory posttranslational modIF:ication (PTM) that results in the mono-, di-, or tri-methylation of lysine at ε-amine groups by protein lysine methyltransferases (PKMTs). Two PKMT groups are recognized based on structure and catalytic mechanism: class I methyltransferases or seven β strand enzymes, and SET domain-containing class V methyltransferases. Both use the methyl donor S-adenosyl-L-methionine to methylate histone and non-histone proteins. Class I methyltransferases methylate amino acids, DNA, and RNA. Six methyl-lysine-interacting protein families are distinguished based on binding domains: mBT, PHD finger, Tudor, PWWP, WD40 repeat, and chromodomains. Many of these display dIF:ferential binding preferences based on lysine methylation state. KDM1 subfamily lysine demethylases catalyze demethylation of mono- and di-methyl lysines, while 2-oxoglutarate-dependent JmjC (KDM2-7) subfamily enzymes also modIF:y tri-methyl lysine residues. |
Subcellular Location.: | nan |
BiowMW: | nan |
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