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EnglishCatalog No. : | IMB0150 |
Reactivity: | Human |
Applications: | WB; ELISA |
Gene Name: | LCK |
Protein Name: | Tyrosine-protein kinase Lck |
Human Gene Id: | 3932 |
Swiss-Prot: | P06239 |
Formulation: | Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol. |
Source: | Monoclonal, Mouse |
Dilution: | WB: 1:500-1:2000 ELISA: 1:10000 |
PurIF:ication: | Affinity purIF:ication |
Concentration: | nan |
Storage&Stability: | -20°C/1 year |
Background: | This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motIF:s, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding dIF:ferent isoforms have been described. [provided by RefSeq, Aug 2016], |
Subcellular Location.: | Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol. Present in lipid rafts in an inactive form. |
BiowMW: | nan |
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