中文
English
| Catalog No. ： | IMB0146 |
| Reactivity： | Human |
| Applications： | WB; IF/ICC |
| Gene Name： | UHRF1 |
| Protein Name： | E3 ubiquitin-protein ligase UHRF1 |
| Human Gene Id： | 29128 |
| Swiss-Prot： | Q96T88 |
| Formulation： | PurIF:ied mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol. |
| Source： | Monoclonal, Mouse |
| Dilution： | WB: 1:1000-1:2000 IF: 1:100-1:500 |
| PurIF:ication： | Affinity purIF:ication |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Background： | This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specIF:ic DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding dIF:ferent isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014], |
| Subcellular Location.： | Nucleus. Localizes to replication foci. Enriched in pericentric heterochromatin. Also localizes to euchromatic regions. |
| BiowMW： | nan |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
join our baijia list to stay up to date and get notices about our new releases!
