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| Catalog No. ： | IMB0139 |
| Reactivity： | nan |
| Applications： | WB |
| Gene Name： | sirt6 |
| Protein Name： | nan |
| Human Gene Id： | 51548 |
| Swiss-Prot： | Q8N6T7 |
| Formulation： | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source： | Monoclonal, Mouse |
| Dilution： | WB: 1:500 |
| PurIF:ication： | The antibody was affinity-purIF:ied from mouse ascites by affinity-chromatography using epitope-specIF:ic immunogen. |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Background： | This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding dIF:ferent isoforms. [provided by RefSeq, Mar 2016], |
| Subcellular Location.： | Nucleus. Chromosome. Chromosome, telomere. Endoplasmic reticulum . Predominantly nuclear (PubMed:18337721). Associated with pericentric heterochromatin and telomeric heterochromatin regions (PubMed:18337721, PubMed:27043296). Localizes to DNA damage sites: directly recognizes and binds double-strand breaks (DSBs) sites via a tunnel-like structure that has high affinity for DSBs (PubMed:21680843, PubMed:23911928, PubMed:27568560, PubMed:31995034, PubMed:32538779). A fraction localizes to the endoplasmic reticulum (PubMed:23552949). |
| BiowMW： | nan |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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