中文
EnglishCatalog No. : | IMB0132 |
Reactivity: | Human |
Applications: | WB; ELISA |
Gene Name: | EIF:2AK3 |
Protein Name: | Eukaryotic translation initiation factor 2-alpha kinase 3 |
Human Gene Id: | 9451 |
Swiss-Prot: | Q9NZJ5 |
Formulation: | Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol. |
Source: | Monoclonal, Mouse |
Dilution: | WB: 1:500-1:2000 ELISA: 1:10000 |
PurIF:ication: | Affinity purIF:ication |
Concentration: | nan |
Storage&Stability: | -20°C/1 year |
Background: | The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015], |
Subcellular Location.: | Endoplasmic reticulum membrane; Single-pass type I membrane protein. |
BiowMW: | nan |
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