中文
EnglishCatalog No. : | IMB0130 |
Reactivity: | Human;Mouse |
Applications: | WB; ELISA |
Gene Name: | RELA |
Protein Name: | Transcription factor p65 |
Human Gene Id: | 5970 |
Swiss-Prot: | Q04206 |
Formulation: | Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol. |
Source: | Monoclonal, Mouse |
Dilution: | WB: 1:500-1:2000 ELISA: 1:10000 |
PurIF:ication: | Affinity purIF:ication |
Concentration: | nan |
Storage&Stability: | -20°C/1 year |
Background: | NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specIF:ic inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specIF:ic genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding dIF:ferent isoforms have been found for this gene. [provided by RefSeq, Sep 2011], |
Subcellular Location.: | Nucleus. Cytoplasm. Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Colocalized with DDX1 in the nucleus upon TNF-alpha induction. Colocalizes with GFI1 in the nucleus after LPS stimulation. Translocation to the nucleus is impaired in L.monocytogenes infection. |
BiowMW: | nan |
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