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| Catalog No. ： | IMB0125 |
| Reactivity： | Human |
| Applications： | WB; IHC-p; IF/ICC |
| Gene Name： | IDE |
| Protein Name： | Insulin-degrading enzyme |
| Human Gene Id： | 3416 |
| Swiss-Prot： | P14735 |
| Formulation： | PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol. |
| Source： | Monoclonal, Mouse |
| Dilution： | WB: 1:1000 IF: 1:200 IHC: 1:50-300 |
| PurIF:ication： | The antibody was affinity-purIF:ied from mouse ascites by affinity-chromatography using specIF:ic immunogen. |
| Concentration： | nan |
| Storage&Stability： | -20°C/1 year |
| Background： | This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been describe |
| Subcellular Location.： | Cytoplasm, cytosol. Cell membrane. Secreted. Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform. |
| BiowMW： | nan |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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