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| Catalog No. ： | IMB0099 |
| Reactivity： | Human |
| Applications： | WB; ChIP; IF/ICC; FCM; ELISA |
| Gene Name： | KDR |
| Protein Name： | Vascular endothelial growth factor receptor 2 |
| Human Gene Id： | 3791 |
| Swiss-Prot： | P35968 |
| Formulation： | Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol. |
| Source： | Monoclonal, Mouse |
| Dilution： | IP: 2-10µg:mL WB: 1:500-1:2000 IF: 1:200-1:1000 FCM: 1:200-1:400 ELISA: 1:10000 |
| PurIF:ication： | Affinity purIF:ication |
| Concentration： | nan |
| Storage&Stability： | -20°C/1 year |
| Background： | Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial prolIF:eration, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009], |
| Subcellular Location.： | Cell junction . Endoplasmic reticulum . Cell membrane . Localized with RAP1A at cell-cell junctions (By similarity). Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610). .; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Cytoplasmic vesicle. Early endosome. Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus.; [Isoform 2]: Secreted .; [Isoform 3]: Secreted. |
| BiowMW： | nan |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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