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| Catalog No. ： | IMB0097 |
| Reactivity： | Human;Mouse |
| Applications： | WB; IHC-p; FCM; ELISA |
| Gene Name： | MAPK1/MAPK3 |
| Protein Name： | Mitogen-activated protein kinase 1 |
| Human Gene Id： | 5594/5595 |
| Swiss-Prot： | P28482/P27361 |
| Formulation： | Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol. |
| Source： | Monoclonal, Mouse |
| Dilution： | WB: 1:500-1:2000 IHC: 1:200-1:1000 FCM: 1:200-1:400 ELISA: 1:10000 |
| PurIF:ication： | Affinity purIF:ication |
| Concentration： | nan |
| Storage&Stability： | -20°C/1 year |
| Background： | This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as prolIF:eration, dIF:ferentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identIF:ied as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but dIF:fering in the UTRs, have been reporte |
| Subcellular Location.： | Cytoplasm, cytoskeleton, spindle . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm . Membrane, caveola . Cell junction, focal adhesion . Associated with the spindle during prometaphase and metaphase (By similarity). PEA15-binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization. . |
| BiowMW： | nan |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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