中文
EnglishCatalog No. : | IMB0070 |
Reactivity: | Human;Mouse;Rat |
Applications: | WB; IF/ICC; IHC-p |
Gene Name: | MICU1 |
Protein Name: | Calcium uptake protein 1, mitochondrial |
Human Gene Id: | 10367 |
Swiss-Prot: | Q9BPX6 |
Formulation: | PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol. |
Source: | Monoclonal, Mouse |
Dilution: | WB: 1:1000-2000 IHC: 1:100-200 IF: 1:200 |
PurIF:ication: | The antibody was affinity-purIF:ied from mouse ascites by affinity-chromatography using epitope-specIF:ic immunogen. |
Concentration: | nan |
Storage&Stability: | -20°C/1 year |
Background: | This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding dIF:ferent isoforms have been described. |
Subcellular Location.: | Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion intermembrane space. |
BiowMW: | nan |
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