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| Catalog No. ： | IMB0063 |
| Reactivity： | Human;Mouse;Rat |
| Applications： | IHC-p; |
| Gene Name： | COL4A1 |
| Protein Name： | Collagen alpha-1(IV) chain [Cleaved into: Arresten] |
| Human Gene Id： | 1282 |
| Swiss-Prot： | p02462 |
| Formulation： | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source： | Monoclonal, Mouse |
| Dilution： | IHC-p: 1:50-300 |
| PurIF:ication： | The antibody was affinity-purIF:ied from mouse antiserum by affinity-chromatography using epitope-specIF:ic immunogen. |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Background： | This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. |
| Subcellular Location.： | Secreted, extracellular space, extracellular matrix, basement membrane. |
| BiowMW： | nan |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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