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EnglishCatalog No. : | IMB0049 |
Reactivity: | Human;Mouse;Rat |
Applications: | IHC-P; IF/ICC; |
Gene Name: | CD68 |
Protein Name: | Macrosialin |
Human Gene Id: | 968 |
Swiss-Prot: | P34810 |
Formulation: | PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol. |
Source: | Monoclonal, Mouse |
Dilution: | IHC: 1-200; IF: 1:50-200 |
PurIF:ication: | The antibody was affinity-purIF:ied from mouse ascites by affinity-chromatography using specIF:ic immunogen. |
Concentration: | nan |
Storage&Stability: | -20°C/1 year |
Background: | This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specIF:ic lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding dIF:ferent isoforms. [provided by RefSeq, Jul 2008], |
Subcellular Location.: | [Isoform Short]: Cell membrane; Single-pass type I membrane protein. [Isoform Long]: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. |
BiowMW: | 37 kDa |
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