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P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10)

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¥2080.00元/format:100ul

目录号:IMB0046

库存:现货
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Catalog No. :IMB0046
Reactivity:Human;Rat;Mouse
Applications:WB; IHC-p
Gene Name:nan
Protein Name:nan
Human Gene Id:5594/5595
Swiss-Prot:P27361/P28482
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Monoclonal, Mouse
Dilution:WB: 1:1000-2000 IHC: 1:50-100
PurIF:ication:The antibody was affinity-purIF:ied from mouse ascites by affinity-chromatography using specIF:ic immunogen.
Concentration:1 mg/ml
Storage&Stability:-20°C/1 year
Background:The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as prolIF:eration, dIF:ferentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding dIF:ferent protein isoforms have been described.
Subcellular Location.:Cytoplasm. Nucleus. Membrane, caveola. Cell junction, focal adhesion. Autophosphorylation at Thr-207 promotes nuclear localization (PubMed:19060905). PEA15-binding redirects the biological outcome of MAPK3 kinase-signaling by sequestering MAPK3 into the cytoplasm (By similarity).
BiowMW:nan

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