中文
EnglishCatalog No. : | IMB0041 |
Reactivity: | Human |
Applications: | WB; IHC-p; ELISA |
Gene Name: | CD38 |
Protein Name: | ADP-ribosyl cyclase 1 |
Human Gene Id: | 952 |
Swiss-Prot: | P28907 |
Formulation: | Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol. |
Source: | Monoclonal, Mouse |
Dilution: | WB: 1:500-1:2000 IHC: 1:200-1:1000 ELISA: 1:10000 |
PurIF:ication: | Affinity purIF:ication |
Concentration: | nan |
Storage&Stability: | -20°C/1 year |
Background: | The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015], |
Subcellular Location.: | Membrane; Single-pass type II membrane protein. |
BiowMW: | nan |
SPECIES
APPLICATION
TITLE