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EnglishCatalog No. : | IMB0021 |
Reactivity: | Human;Mouse;Rat |
Applications: | IHC-P; IF/ICC; |
Gene Name: | MKI67 |
Protein Name: | Antigen KI-67 |
Human Gene Id: | 4288 |
Swiss-Prot: | P46013 |
Formulation: | PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol. |
Source: | Monoclonal, Mouse |
Dilution: | IHC: 1:200 IF: 1:50-200 |
PurIF:ication: | The antibody was affinity-purIF:ied from mouse ascites by affinity-chromatography using specIF:ic immunogen. |
Concentration: | nan |
Storage&Stability: | -20°C/1 year |
Background: | This gene encodes a nuclear protein that is associated with and may be necessary for cellular prolIF:eration. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. |
Subcellular Location.: | Chromosome. Nucleus. Nucleus, nucleolus. Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the mitotic chromosome surface (PubMed:27362226). Associates with satellite DNA in G1 phase (PubMed:9510506). Binds tightly to chromatin in interphase, chromatin-binding decreases in mitosis when it associates with the surface of the condensed chromosomes (PubMed:15896774, PubMed:22002106). Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. |
BiowMW: | 358694 |
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